1. Water molecules form hydrogen bonds with each other and are strongly polar. 2. Polar solutes dissolve in polar solvents, forming polar bonds or hydrogen bonds . 3. The two characteristic hydrogen bonds are shown as green and purple lines 4. Hydrogen bonds play a key role in base pair binding and interaction.5. Historically, the most favored model has been the hydrogen bond switching model. 6. The base pairs of a DNA strand are connected by hydrogen bonds . 7. When proton tunneling occurs, the hydrogen bond and covalent bonds are switched. 8. The hydrogen bond is often described as a strong electrostatic dipole-dipole interaction. 9. A well-defined pharmacophore model includes both hydrophobic volumes and hydrogen bond vectors. 10. Finally, the active site makes extensive hydrogen bonds with the DNA backbone.